Major Depression (Clinical Depression) A constant sense of hopelessness and despair is a sign you may have major depression, also known as clinical depression. With major depression, it may be. Depression and Older Adults Depression is more than just feeling sad or blue. It is a common but serious mood disorder that needs treatment. It causes severe symptoms that affect how you feel, think, and handle daily activities, such as sleeping, eating, and working.
May 13, · Clinical depression is the more-severe form of depression, also known as major depression or major depressive disorder. It isn't the same as depression caused by a loss, such as the death of a loved one, or a medical condition, such as a thyroid disorder.